From study design to decision-ready analysis, Evidence by Design helps pharma, universities, and governments produce health economics that withstands peer review, regulators, and real-world stakes.
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Everything Dr. Beyene's teams reach for during a real study, from free calculators to full consulting engagements.
Blog, newsletter, weekly videos, learning paths, an academy, and worked case studies in HEOR and epidemiology.
Explore Learn →Protocol & SAP builders, DAG builder, sample-size and power calculators, and an AI research assistant.
Open the tools →Real-world evidence, cost-effectiveness, claims data, registries, and target trial emulation — methods made practical.
Enter the hub →Hands-on support for pharma, universities, CROs, nonprofits, and government — from design to defensible results.
Work with us →No sign-up, no paywall. Get a defensible number in seconds — then read exactly how it was derived.
Two proportions, two means, or a single proportion — with power, alpha, allocation ratio, and dropout adjustment.
Calculate now → ● Live toolEnter your achieved sample size and effect size to recover the study's true power — ideal for reviews and rebuttals.
Calculate now → Guided builderStep through a rigorous study protocol and statistical analysis plan with expert prompts and export-ready output.
Preview builders →Dr. Beyene is an educator, researcher, and consultant specialising in veterinary epidemiology, disease-burden analysis, and health economics — recognised for highly-cited global health research and his academic work at Addis Ababa University.
When QALYs help — and when a simpler cost-per-case-averted tells a cleaner story for decision-makers.
Read article → Causal inferenceA practical walkthrough of specifying and emulating a target trial from routinely-collected data.
Read article → Disease burdenTransparent assumptions, sensitivity analysis, and how to report uncertainty honestly.
Read article →"Dr. Beyene turned a messy claims dataset into an analysis our funders could actually defend. The rigour was obvious on every page."
— Programme Director, Global Health NonprofitTemplates, code, courses, and community — priced for students, practitioners, and institutions.
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Whether you need a full study designed or a single number checked, start with a conversation.